Scientific Foundation

Research-led neural digital twin development

NeuroTwin is grounded in computational neuroscience, neuromorphic computing, synaptic plasticity research, and clinical rehabilitation collaboration.

Research areas

Computational neuroscience

Dynamic neural modeling for patient-specific recovery trajectories.

Post-stroke rehabilitation modeling

Motor recovery prediction, trajectory assessment, and risk identification.

Neuromorphic computing

Event-driven, memory-compute-oriented architectures for scalable neural simulation.

Organic memristive devices

Synapse-like adaptive devices for bio-inspired learning and memory-like behavior.

Neurointerfaces and future prosthetic directions

Long-term research into adaptive interfaces between biological and artificial neural systems.

Selected references from our team

Critical Analysis of Energy Consumption in Neuro-Computational Systems

Ivan Kipelkin, Ilija Kamenko, Jovan Ivošević, Alina Fedorova, Grigory Zharkov, Jovana Maricic, Stojanka Bratic, Nebojša Pilipović, Natasa Samardzic, Staniša Dautović, Milovan Medojević, Branimir Bajac, Jordi Vallverdú, Dragiša Žunić, Francesco Restuccia, Vincenzo Alessio, Francesco Longo, Giovanni Merlino, Dario Bruneo, Salvatore Distefano, Alexander Toschev, Alexey Mikhaylov, Victor Erokhin, Max Talanov

IEEE Access, 2026

A unified benchmark of energy consumption per synaptic event across GPUs, NPUs, FPGAs, digital spiking processors, memristive devices, and biological reference ranges.

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Printing Polyaniline Based Organic Memristive Devices for Neuromorphic Computing Applications

Silvia Battistoni, Anna N. Matsukatova, Rocco Carcione, Luciano Ferrucci, Matteo Parmeggiani, Matteo Cocuzza, Simone Luigi Marasso, Andrey V. Emelyanov, Vyacheslav A. Demin, Victor Erokhin

Materials Today Chemistry, 2026

A study of printable polyaniline-based organic memristive devices and their potential as scalable, adaptable hardware elements for neuromorphic computing applications.

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Advancing Neural Networks: Innovations and Impacts on Energy Consumption

Alina Fedorova, Nikola Jovišić, Jordi Vallverdù, Silvia Battistoni, Miloš Jovičić, Milovan Medojević, Alexander Toschev, Evgeniia Alshanskaia, Max Talanov, Victor Erokhin

Advanced Electronic Materials, 2024

A review comparing the energy consumption of conventional artificial neural networks, spiking neural networks, specialized memristive hardware, and the human brain.

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Combination of Organic-Based Reservoir Computing and Spiking Neuromorphic Systems for a Robust and Efficient Pattern Classification

Anna N. Matsukatova, Nikita V. Prudnikov, Vsevolod A. Kulagin, Silvia Battistoni, Anton A. Minnekhanov, Andrey D. Trofimov, Aleksandr A. Nesmelov, Sergey A. Zavyalov, Yulia N. Malakhova, Matteo Parmeggiani, Alberto Ballesio, Simone Luigi Marasso, Sergey N. Chvalun, Vyacheslav A. Demin, Andrey V. Emelyanov, Victor Erokhin

Advanced Intelligent Systems, 2023

A fully organic system combining volatile polyaniline reservoir computing with a nonvolatile parylene-memristor spiking readout layer for robust spatiotemporal pattern classification.

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Memristive Circuit-Based Model of Central Pattern Generator to Reproduce Spinal Neuronal Activity in Walking Pattern

Dinar N. Masaev, Alina A. Suleimanova, Nikita V. Prudnikov, Mariia V. Serenko, Andrey V. Emelyanov, Vyacheslav A. Demin, Igor A. Lavrov, Max O. Talanov, Victor V. Erokhin

Frontiers in Neuroscience, 2023

A self-learning memristive circuit model that uses biologically plausible spike-timing-dependent plasticity to reproduce spinal neuronal activity associated with walking patterns.

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Memristive Devices for Neuromorphic Applications: Comparative Analysis

Victor Erokhin

BioNanoScience, 2020

A comparative review of organic and inorganic memristive devices for neuromorphic applications, including memory-processing integration, sensors, oscillators, bio-mimicking circuits, and living-system coupling.

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Associative STDP-Like Learning of Neuromorphic Circuits Based on Polyaniline Memristive Microdevices

Nikita V. Prudnikov, Dmitry A. Lapkin, Andrey V. Emelyanov, Anton A. Minnekhanov, Yulia N. Malakhova, Sergey N. Chvalun, Vyacheslav A. Demin, Victor V. Erokhin

Journal of Physics D: Applied Physics, 2020

An experimental demonstration of improved STDP timescales and unsupervised associative learning in a simple spiking neural network built with polyaniline memristive microdevices.

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Parylene Based Memristive Devices with Multilevel Resistive Switching for Neuromorphic Applications

Anton A. Minnekhanov, Andrey V. Emelyanov, Dmitry A. Lapkin, Kristina E. Nikiruy, Boris S. Shvetsov, Alexander A. Nesmelov, Vladimir V. Rylkov, Vyacheslav A. Demin, Victor V. Erokhin

Scientific Reports, 2019

A study of low-cost, biocompatible parylene memristors demonstrating low switching voltage, stable multilevel resistance states, and biologically inspired STDP training.

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Coupling Cortical Neurons Through Electronic Memristive Synapse

Elvira Juzekaeva, Azat Nasretdinov, Silvia Battistoni, Tatiana Berzina, Salvatore Iannotta, Rustem Khazipov, Victor Erokhin, Marat Mukhtarov

Advanced Materials Technologies, 2018

The first demonstration of activity-dependent coupling between two living cortical neurons through an organic memristive device acting as an artificial synapse.

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Material Memristive Device Circuits with Synaptic Plasticity: Learning and Memory

Victor Erokhin, Tatiana Berzina, Paolo Camorani, Anteo Smerieri, Dimitris Vavoulis, Jianfeng Feng, Marco P. Fontana

BioNanoScience, 2011

An experimental demonstration of organic memristive device circuits showing adaptive behavior inspired by synaptic plasticity and learning in a biological neural reference system.

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European brain research ecosystem

Our research direction is aligned with the broader European brain research ecosystem, including EBRAINS, which provides data, tools, models, and services for brain-related research.

Interested in validating patient-specific neural digital twins in rehabilitation?

We are inviting neurorehabilitation clinics and research partners to explore retrospective and prospective collaboration opportunities.